hidden
Hình bìa
Loại tài liệu:
Article
Tác giả:
Moura, J.V.B.
Đề mục:
Arabian Journal of Chemistry
Nhà xuất bản:
Elsevier Ltd.
Ngày xuất bản:
September 2018
Định dạng:
pdf
Nguồn gốc:
Arabian Journal of Chemistry, Volume 11, Issue 6, September 2018, Pages 739-746
Ngôn ngữ:
eng
Lượt xem:
0
Lượt tải:
0

Nội dung

This study reports the synthesis and characterization of PbMoO4 nanocrystals and the antibacterial properties and modulation of their antibiotic activity. Lead molybdate nanocrystals were obtained through the conventional hydrothermal method, and the structural, vibrational and morphological properties of the sample were determined using X-ray diffraction, Raman and infrared spectroscopy, and scanning electron microscopy images. The obtained samples present scheelite-type tetragonal structure (space group I41/a) without secondary phases, and the Raman spectrum shows the formation of PbMoO4 structurally ordered at short-range, confirming the quality of the samples. The antibacterial and antibiotic-modulation activities were performed in triplicate using the microdilution method. The minimum inhibitory concentration (MIC) of antibiotics alone or in association with PbMoO4, were demonstrated using geometric mean. When assayed directly, the PbMoO4 presented a MIC ≥ 1024 μg/mL against all bacterial strains tested. When in association with the gentamicin against Staphylococcus aureus, a synergism was observed reducing 37.5% the MIC. However, in the assays against the Gram-negative strains was observed that the presence of lead affected the effect of the antibiotic, leading to an antagonism.

Tập tin đính kèm

Loại file Tên file Dung lượng Chi tiết
201806AJC739-746.pdf 1319029 Kb XemTải