23 English eng Porchia, Marina Contributor <p><span style="margin: 0px; padding: 0px; color: rgb(31, 31, 31); font-family: ElsevierGulliver, Georgia, "Times New Roman", Times, STIXGeneral, "Cambria Math", "Lucida Sans Unicode", "Microsoft Sans Serif", "Segoe UI Symbol", "Arial Unicode MS", serif, sans-serif; font-size: 16px;"><span style="margin: 0px; padding: 0px;">Copper(I) complexes including diimine ligands of the bicinchoninic acid (BCA) and bathocuproinedisulfonic acid (BCS) families and water-soluble&nbsp;<a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/phosphine-derivative" title="Learn more about phosphines from ScienceDirect's AI-generated Topic Pages" class="topic-link" style="margin: 0px; padding: 0px; background-color: rgba(0, 0, 0, 0); word-break: break-word; text-decoration-line: underline; text-decoration-thickness: 1px; text-decoration-color: rgb(31, 31, 31); color: rgb(31, 31, 31); text-underline-offset: 1px;">phosphines</a><span style="margin: 0px; padding: 0px;">&nbsp;have been synthetized, characterized and investigated for their in vitro anticancer potential against human tumor cell lines representing examples of lung, breast, pancreatic and&nbsp;<a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/colon-cancer" title="Learn more about colon cancers from ScienceDirect's AI-generated Topic Pages" class="topic-link" style="margin: 0px; padding: 0px; background-color: rgba(0, 0, 0, 0); word-break: break-word; text-decoration-line: underline; text-decoration-thickness: 1px; text-decoration-color: rgb(31, 31, 31); color: rgb(31, 31, 31); text-underline-offset: 1px;">colon cancers</a>&nbsp;and&nbsp;</span></span><a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/melanoma" title="Learn more about melanoma from ScienceDirect's AI-generated Topic Pages" class="topic-link" style="margin: 0px; padding: 0px; background-color: rgba(0, 0, 0, 0); word-break: break-word; text-decoration-line: underline; text-decoration-thickness: 1px; text-decoration-color: rgb(31, 31, 31); color: rgb(31, 31, 31); text-underline-offset: 1px;">melanoma</a>. All&nbsp;</span><a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/copper-complex" title="Learn more about copper complexes from ScienceDirect's AI-generated Topic Pages" class="topic-link" style="margin: 0px; padding: 0px; background-color: rgba(0, 0, 0, 0); word-break: break-word; text-decoration-line: underline; text-decoration-thickness: 1px; text-decoration-color: rgb(31, 31, 31); color: rgb(31, 31, 31); text-underline-offset: 1px; font-family: ElsevierGulliver, Georgia, "Times New Roman", Times, STIXGeneral, "Cambria Math", "Lucida Sans Unicode", "Microsoft Sans Serif", "Segoe UI Symbol", "Arial Unicode MS", serif, sans-serif; font-size: 16px;">copper complexes</a><span style="margin: 0px; padding: 0px; color: rgb(31, 31, 31); font-family: ElsevierGulliver, Georgia, "Times New Roman", Times, STIXGeneral, "Cambria Math", "Lucida Sans Unicode", "Microsoft Sans Serif", "Segoe UI Symbol", "Arial Unicode MS", serif, sans-serif; font-size: 16px;"><span style="margin: 0px; padding: 0px;">&nbsp;exhibited moderate to high cytotoxic activity and the ability to overcome&nbsp;<a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/cisplatin" title="Learn more about cisplatin from ScienceDirect's AI-generated Topic Pages" class="topic-link" style="margin: 0px; padding: 0px; background-color: rgba(0, 0, 0, 0); word-break: break-word; text-decoration-line: underline; text-decoration-thickness: 1px; text-decoration-color: rgb(31, 31, 31); color: rgb(31, 31, 31); text-underline-offset: 1px;">cisplatin</a><span style="margin: 0px; padding: 0px;">&nbsp;resistance. Remarkably, growth-inhibitory effects evaluated in human non-transformed cells revealed a preferential cytotoxicity versus neoplastic cells. The remarkable cytotoxic effect towards BxPC3&nbsp;<a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/pancreas-cancer" title="Learn more about pancreatic cancer from ScienceDirect's AI-generated Topic Pages" class="topic-link" style="margin: 0px; padding: 0px; background-color: rgba(0, 0, 0, 0); word-break: break-word; text-decoration-line: underline; text-decoration-thickness: 1px; text-decoration-color: rgb(31, 31, 31); color: rgb(31, 31, 31); text-underline-offset: 1px;">pancreatic cancer</a>&nbsp;cells, notoriously poor sensitive to cisplatin, was not related to a DNA or&nbsp;</span></span><a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/proteasome" title="Learn more about proteasome from ScienceDirect's AI-generated Topic Pages" class="topic-link" style="margin: 0px; padding: 0px; background-color: rgba(0, 0, 0, 0); word-break: break-word; text-decoration-line: underline; text-decoration-thickness: 1px; text-decoration-color: rgb(31, 31, 31); color: rgb(31, 31, 31); text-underline-offset: 1px;">proteasome</a>&nbsp;damage.</span></p> Elsevier Ltd. January 2020 pdf Arabian Journal of Chemistry In vitro antitumor activity of water-soluble copper(I) complexes with diimine and monodentate phosphine ligands mixed material Elsevier Ltd.