23 DOI: https://doi.org/10.1016/j.jgeb.2026.100785 English eng Amukti, Danang Prasetyaning Contributor <div class="abstract author" id="as0005" style="margin: 0px 0px 8px; padding: 0px; color: rgb(31, 31, 31); font-family: ElsevierGulliver, Georgia, "Times New Roman", Times, STIXGeneral, "Cambria Math", "Lucida Sans Unicode", "Microsoft Sans Serif", "Segoe UI Symbol", "Arial Unicode MS", serif, sans-serif; font-size: 16px;"><h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0010" style="margin-right: 0px; margin-left: 0px; padding: 0px; margin-top: 24px !important; margin-bottom: 8px !important; font-size: 20px !important; line-height: 30px !important;">Introduction</h3><div class="u-margin-s-bottom" id="sp0060" style="margin-top: 0px; margin-right: 0px; margin-left: 0px; padding: 0px; margin-bottom: 16px !important;">Alzheimer's disease is a progressive neurodegenerative disorder that is the leading cause of dementia worldwide. Genetic factors, particularly <em style="margin: 0px; padding: 0px;">Apolipoprotein E</em> (APOE) polymorphisms, are known to play a significant role in increasing susceptibility to Alzheimer's disease. The increasing number of publications related to APOE and Alzheimer's disease has prompted the need for bibliometric analysis and <em style="margin: 0px; padding: 0px;">systematic reviews</em> to comprehensively understand research developments and their genetic relationships. This study aims to analyze the global development of research on APOE polymorphisms in Alzheimer's disease through a <em style="margin: 0px; padding: 0px;">bibliometric study</em> and <em style="margin: 0px; padding: 0px;">systematic review</em> approach.</div></div><div class="abstract author" id="as0010" style="margin: 0px 0px 8px; padding: 0px; color: rgb(31, 31, 31); font-family: ElsevierGulliver, Georgia, "Times New Roman", Times, STIXGeneral, "Cambria Math", "Lucida Sans Unicode", "Microsoft Sans Serif", "Segoe UI Symbol", "Arial Unicode MS", serif, sans-serif; font-size: 16px;"><h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0015" style="margin-right: 0px; margin-left: 0px; padding: 0px; margin-top: 24px !important; margin-bottom: 8px !important; font-size: 20px !important; line-height: 30px !important;">Methods</h3><div class="u-margin-s-bottom" id="sp0065" style="margin-top: 0px; margin-right: 0px; margin-left: 0px; padding: 0px; margin-bottom: 16px !important;">The study used a combined bibliometric and <em style="margin: 0px; padding: 0px;">systematic review design</em>. Data were obtained from the Scopus database for the period 2000–2025 using keywords <em style="margin: 0px; padding: 0px;">Title-Abs-Key ((“APOE” Or “APOE E4” Or “Apolipoprotein E4”) And (“Alzheimer's disease”And (“Genetic Susceptibility”Or”Risk Factor”)) And (Limit-To (Doctype,”Ar”)) And (Limit-To(Language,”English”)) And Pubyear ></em> <em style="margin: 0px; padding: 0px;">1999 And Pubyear <</em> <em style="margin: 0px; padding: 0px;">2026</em>. Bibliometric analysis was performed using VOSviewer and Microsoft Excel to evaluate publication trends, countries, institutions, journals, author collaborations, and <em style="margin: 0px; padding: 0px;">co-occurrence keywords</em> . <em style="margin: 0px; padding: 0px;">A systematic review</em> was conducted on 26 articles that met the inclusion criteria to evaluate the association of APOE polymorphisms with Alzheimer's risk.</div></div><div class="abstract author" id="as0015" style="margin: 0px 0px 8px; padding: 0px; color: rgb(31, 31, 31); font-family: ElsevierGulliver, Georgia, "Times New Roman", Times, STIXGeneral, "Cambria Math", "Lucida Sans Unicode", "Microsoft Sans Serif", "Segoe UI Symbol", "Arial Unicode MS", serif, sans-serif; font-size: 16px;"><h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0020" style="margin-right: 0px; margin-left: 0px; padding: 0px; margin-top: 24px !important; margin-bottom: 8px !important; font-size: 20px !important; line-height: 30px !important;">Results</h3><div class="u-margin-s-bottom" id="sp0070" style="margin-top: 0px; margin-right: 0px; margin-left: 0px; padding: 0px; margin-bottom: 16px !important;">A total of 3824 articles from 718 publication sources were identified with an average citation of 51.51 per document. <em style="margin: 0px; padding: 0px;">The United States</em> was the country with the highest publication contribution. <em style="margin: 0px; padding: 0px;">Keyword co-occurrence</em> analysis showed that <em style="margin: 0px; padding: 0px;">APOE4</em>, <em style="margin: 0px; padding: 0px;">genetics</em>, and <em style="margin: 0px; padding: 0px;">biomarkers</em> were the main research themes. The results of <em style="margin: 0px; padding: 0px;">the systematic review</em> showed that APOE polymorphisms, especially <em style="margin: 0px; padding: 0px;">rs429358</em> and <em style="margin: 0px; padding: 0px;">rs7412</em>, had a significant association with an increased risk of Alzheimer's disease in various ethnic populations with a very low <em style="margin: 0px; padding: 0px;">p-value of up to 1E-320.</em></div></div><div class="abstract author" id="as0020" style="margin: 0px 0px 8px; padding: 0px; color: rgb(31, 31, 31); font-family: ElsevierGulliver, Georgia, "Times New Roman", Times, STIXGeneral, "Cambria Math", "Lucida Sans Unicode", "Microsoft Sans Serif", "Segoe UI Symbol", "Arial Unicode MS", serif, sans-serif; font-size: 16px;"><h3 class="u-h4 u-margin-m-top u-margin-xs-bottom" id="st0025" style="margin-right: 0px; margin-left: 0px; padding: 0px; margin-top: 24px !important; margin-bottom: 8px !important; font-size: 20px !important; line-height: 30px !important;">Conclusion</h3><div class="u-margin-s-bottom" id="sp0075" style="margin-top: 0px; margin-right: 0px; margin-left: 0px; padding: 0px; margin-bottom: 16px !important;">APOE polymorphisms play an important role in the genetic susceptibility of Alzheimer's disease and have the potential to be key biomarkers in early detection and the development of <em style="margin: 0px; padding: 0px;">precision medicine</em> in neurodegenerative diseases.</div></div> Elsevier September 2026 pdf Journal of Genetic Engineering and Biotechnology Genetic susceptibility of Alzheimer's disease associated with APOE polymorphism: systematic review and bibliometric study mixed material Elsevier