Synthesis, characterization and antimicrobial studies on 13-membered-N6-macrocyclic transition metal complexes containing trimethoprim

Loại tài liệu:

Article

Tác giả:

Stella Shalini, A.S.

Đề mục:

Arabian Journal of Chemistry

Nhà xuất bản:

Elsevier Ltd.

Ngày xuất bản:

November 2019

Định dạng:

pdf

Nguồn gốc:

Arabian Journal of Chemistry, Volume 12, Issue 7 , November 2019, Pages 1176-1185

Ngôn ngữ:

eng

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Lượt tải:

Nội dung

Asymmetrical macrocyclic complexes of MnII, CoII, NiII, CuII and ZnII have been synthesized by the template process using bis(benzil)ethylenediamine as precursor. Bis(benzil)ethylenediamine reacts with transition metal chlorides and trimethoprim in a 1:1:1 molar ratio in methanol to give several solid metal complexes of the general composition [M(L)X2] (M = MnII, CoII, NiII, CuII and ZnII, L = ligand and X = Cl−). They were characterized by physicochemical and spectroscopic techniques. Based on analytical, spectral and magnetic moments, all the complexes are identified as distorted octahedral structures. All the complexes are of the [M(L)X2] type. The shifts of the ν(C double bond N) (azomethine) stretches have been monitored. To find out the donor sites of the ligands, the activity data show that the metal complexes are more potent than the parent ligand. The [M(L)X2] complexes showed a broad spectrum of antimicrobial activity in vitro against both gram-positive and gram-negative human pathogenic bacterial isolates and the antimicrobial spectrum enhanced only with a combination of metal chlorides and trimethoprim complex. From the results it is imperative that the synthesized macrocyclic [M(L)X2] complexes exhibit potent broad spectrum antibacterial activity.

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Synthesis, characterization and antimicrobial studies on 13-membered-N6-macrocyclic transition metal complexes containing trimethoprim

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