In vitro antitumor activity of water-soluble copper(I) complexes with diimine and monodentate phosphine ligands

Loại tài liệu:

Article

Tác giả:

Porchia, Marina

Đề mục:

Arabian Journal of Chemistry

Nhà xuất bản:

Elsevier Ltd.

Ngày xuất bản:

January 2020

Định dạng:

pdf

Nguồn gốc:

Arabian Journal of Chemistry, Volume 13, Issue 1, January 2020, Pages 998-1010

Ngôn ngữ:

eng

Lượt xem:

Lượt tải:

Nội dung

Copper(I) complexes including diimine ligands of the bicinchoninic acid (BCA) and bathocuproinedisulfonic acid (BCS) families and water-soluble phosphines have been synthetized, characterized and investigated for their in vitro anticancer potential against human tumor cell lines representing examples of lung, breast, pancreatic and colon cancers and melanoma. All copper complexes exhibited moderate to high cytotoxic activity and the ability to overcome cisplatin resistance. Remarkably, growth-inhibitory effects evaluated in human non-transformed cells revealed a preferential cytotoxicity versus neoplastic cells. The remarkable cytotoxic effect towards BxPC3 pancreatic cancer cells, notoriously poor sensitive to cisplatin, was not related to a DNA or proteasome damage.

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In vitro antitumor activity of water-soluble copper(I) complexes with diimine and monodentate phosphine ligands

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